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KMID : 0604520120380010067
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 1 p.67 ~ p.73
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Hypopigmentary Effects of Dipeptides in B16 Melanoma Cells
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Nam Hee-Seung
Kim Eun-Hyun
Kim Su-Yeon
Lee Hyun-E
Hong Ji-yun
Lee Jae-Guk
Cho Sung-Tai
Cho Yang-Hwan
Yun Hye-Young
Baek Kwang-Jin
Kwon Nyoun-Soo
Min Young-Sil
Park Kyoung-Chan
Kim Dong-Seok
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Abstract
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In the present study, we investigated the effects of dipeptides on melanogenesis in B16 melanoma cells. It was found that WV (Trp+Val), WM (Trp+Met), and CQ (Cys+Gln) decreased melanin production dosedependently. However, dipeptides did not directly inhibit tyrosinase activity, the rate-limiting melanogenic enzyme. Therefore, we further investigated the expression of tyrosinase. Our results showed that α-MSH-induced tyrosinase expression was down-regulated by WV, WM, and CQ. Thus, we propose that WV, WM, and CQ show hypopigmentary activity through tyrosinase down-regulation.
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KEYWORD
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α-MSH, dipeptides, melanogenesis, tyrosinase, melanin
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